ParkinsonCanadaV1, Main, Exploration, bibRecord, 000831

Altered protein expression pattern in skin fibroblasts from parkin-mutant early-onset Parkinson's disease patients.

Identifieur interne : 000831 ( Main/Exploration ); précédent : 000830; suivant : 000832

Altered protein expression pattern in skin fibroblasts from parkin-mutant early-onset Parkinson's disease patients.

Auteurs : Rosa Lippolis [Italie] ; Rosa Anna Siciliano [Italie] ; Consiglia Pacelli [Canada] ; Anna Ferretta [Italie] ; Maria Fiorella Mazzeo [Italie] ; Salvatore Scacco [Italie] ; Francesco Papa [Italie] ; Antonio Gaballo [Italie] ; Claudia Dell'Aquila [Italie] ; Michele De Mari [Italie] ; Sergio Papa [Italie] ; Tiziana Cocco [Italie]

Source :

Biochimica et biophysica acta [ 0006-3002 ] ; 2015.

RBID : pubmed:26096686

Abstract

Parkinson's disease (PD) is the most common neurodegenerative movement disorder caused primarily by selective degeneration of the dopaminergic neurons in substantia nigra. In this work the proteomes extracted from primary fibroblasts of two unrelated, hereditary cases of PD patients, with different parkin mutations, were compared with the proteomes extracted from commercial adult normal human dermal fibroblasts (NHDF) and primary fibroblasts from the healthy mother of one of the two patients. The results show that the fibroblasts from the two different cases of parkin-mutant patients display analogous alterations in the expression level of proteins involved in different cellular functions, like cytoskeleton structure-dynamics, calcium homeostasis, oxidative stress response, protein and RNA processing.

DOI: 10.1016/j.bbadis.2015.06.015
PubMed: 26096686

Affiliations:

Le document en format XML

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<front><div type="abstract" xml:lang="en">Parkinson's disease (PD) is the most common neurodegenerative movement disorder caused primarily by selective degeneration of the dopaminergic neurons in substantia nigra. In this work the proteomes extracted from primary fibroblasts of two unrelated, hereditary cases of PD patients, with different parkin mutations, were compared with the proteomes extracted from commercial adult normal human dermal fibroblasts (NHDF) and primary fibroblasts from the healthy mother of one of the two patients. The results show that the fibroblasts from the two different cases of parkin-mutant patients display analogous alterations in the expression level of proteins involved in different cellular functions, like cytoskeleton structure-dynamics, calcium homeostasis, oxidative stress response, protein and RNA processing.</div>
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La maladie de Parkinson au Canada (serveur d'exploration)

Altered protein expression pattern in skin fibroblasts from parkin-mutant early-onset Parkinson's disease patients.

Altered protein expression pattern in skin fibroblasts from parkin-mutant early-onset Parkinson's disease patients.

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Abstract

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	La maladie de Parkinson au Canada (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.